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Skin Cancer

ABOUT SKIN CANCER

Skin cancer is on the rise.

According to the American Cancer Society, one in five Americans will develop skin cancer in his/her lifetime. In fact, more than 3 million Americans will be diagnosed this year alone, and melanoma will account for more than 76,000 cases of invasive skin cancer. But as dangerous as it can be, it is also very curable if caught early. We want you to know the importance of examining your skin and having changes checked by your doctor. Checking your skin monthly can save your life!

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SAFE FUN UNDER THE SUN

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Don’t let your fun in the sun turn into a burn! Mary Bird Perkins Cancer Center is educating local youth about sun safety to help reduce chances of skin cancer as an adult.

Download these PDFs to learn about how you can protect your skin and reduce your chances for cancer later in life:

RISK FACTORS

Certain physical features can be a risk factor such as a lighter natural skin color or skin that burns, freckles, reddens easily, or becomes painful in the sun; blue or green eyes; blond or red hair; or having certain types and a large number of moles. Other risk factors can include family or personal history of skin cancer, exposure to the sun through work and play, a history of sunburns, especially early in life, or a history of indoor tanning.

SYMPTOMS

The most common sign of skin cancer is changes on your skin. To examine your skin for changes, check for the five most common features in a potentially abnormal spot: asymmetry, border, color, diameter and evolution. If a spot is asymmetrical, then one half of the spot does not match the other. Check the border to see if the edges are irregular, ragged, notched or blurred. If color is not the same all over and may include different shades of brown or black, or sometimes with patches of pink, red, white, or blue, then it may be an abnormal spot. Check the diameter to see if the spot is larger than 6 millimeters across (about ¼ inch – the size of a pencil eraser), although melanomas can sometimes be smaller than this. A spot is evolving if it changing in size, shape, or color. If you notice these changes on your skin, please talk to your doctor.

Source: cancer.org

SCREENINGS

WHEN TO GET SCREENED

Adult men and women should examine skin regularly and see a doctor to evaluate new growths or changes in existing growths.

DISEASE SITE TEAM

Disease site teams, or multidisciplinary care teams, are specialists from each diagnostic, treatment and supportive care discipline working together in the same facility where state-of-the-art cancer treatment is given, and relevant research is conducted.

CLINICAL TRIALS

Clinical trials are research studies that involve human beings in order to test new ways to prevent, detect, diagnose or treat diseases. A drug must be part of a clinical trial before the FDA will approve it to be put on the market. Oncology clinical trials are conducted in order to test new drugs or a new combination of drug treatments, new surgery and radiation therapies and new medical devices.

Every cancer center patient is evaluated for participation in a clinical trial. Those who meet the criteria to participate in clinical research receive a standard of care treatment, but with the added benefit of a trial that may enhance their outcomes.

If interested in volunteering to participate in a clinical research trial, or if you have concerns about the conduct of clinical research, please contact the Clinical Research office at (225) 215-1353, or by email at clinicalresearch@marybird.com.

Trial Number: E3612

Title:  A Randomized Phase II Trial of Ipilimumab with or Without Bevacizumab in Patients with Unresectable Stage III or Stage IV Melanoma

Purpose:  This randomized phase II trial studies how well ipilimumab with or without bevacizumab works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab and bevacizumab, block tumor growth in different ways by targeting certain cells.

Physicians: Drs. Deborah AbernathyBryan Bienvenu, Vince Cataldo, David Hanson, Kellie Schmeeckle, Joseph Shows, Derrick Spell, Siva Yadlapati and Lauren Zatarain; James Carinder, Carrie Marquette, and Jack Saux; Robert Gamble, Naveed Khan, and Harry McGaw

Offered in:  Baton Rouge, Covington, Houma

Trial Number:  EA6134

Title:  A Randomized Phase III Trial of Dabrafenib + Trametinib Followed by Ipilimumab + Nivolumab at Progression vs. Ipilimumab + Nivolumab Followed by Dabrafenib + Trametinib at Progression in Patients with Advanced BRAFV600 Mutant Melanoma

Purpose:  This randomized phase III trial studies how well initial treatment with ipilimumab and nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab in treating patients with stage III-IV melanoma that contains a mutation known as BRAFV600 and cannot be removed by surgery. Ipilimumab and nivolumab may block tumor growth by targeting certain cells. Dabrafenib and trametinib may block tumor growth by targeting the BRAFV600 gene. It is not yet known whether treating patients with ipilimumab and nivolumab followed by dabrafenib and trametinib is more effective than treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab.

Physicians: Drs. Deborah AbernathyBryan Bienvenu, Vince Cataldo, David Hanson, Kellie Schmeeckle, Joseph Shows, Derrick Spell, Siva Yadlapati and Lauren Zatarain; James Carinder, Carrie Marquette, and Jack Saux; Robert Gamble, Naveed Khan, and Harry McGaw

Offered in:  Baton Rouge, Covington, Houma

Trial Number:  EA6141

Title:  Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients with Unresectable Stage III or Stage IV Melanoma

Purpose:  This randomized phase II/III trial studies the side effects and best dose of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab and nivolumab, may kill tumor cells by blocking blood flow to the tumor, by stimulating white blood cells to kill the tumor cells, or by attacking specific tumor cells and stop them from growing or kill them. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.

Physicians: Drs. Deborah AbernathyBryan Bienvenu, Vince Cataldo, David Hanson, Kellie Schmeeckle, Joseph Shows, Derrick Spell, Siva Yadlapati and Lauren Zatarain; James Carinder, Carrie Marquette, and Jack Saux; Robert Gamble, Naveed Khan, and Harry McGaw

Offered in:  Baton Rouge, Covington, Houma

Trial Number:  S1404

Title:  A Phase III Randomized Trial Comparing Physician/Patient Choice of Either High Dose Interferon or Ipilimumab to MK-3475 (Pembrolizumab) in Patients with High Risk Resected Melanoma

Purpose:  This randomized phase III trial studies how well high-dose recombinant interferon alfa-2B or ipilimumab works compared with pembrolizumab in treating patients with stage III-IV melanoma that has been removed by surgery but is likely to come back or spread. High-dose recombinant interferon alfa-2B may help shrink or slow the growth of melanoma. Monoclonal antibodies, such as ipilimumab and pembrolizumab, may block tumor growth in different ways by targeting certain cells. It is not yet known whether high-dose recombinant interferon alfa-2B or ipilimumab is more effective than pembrolizumab in treating patients with melanoma.

Physicians: Drs. Deborah AbernathyBryan Bienvenu, Vince Cataldo, David Hanson, Kellie Schmeeckle, Joseph Shows, Derrick Spell, Siva Yadlapati and Lauren Zatarain; James Carinder, Carrie Marquette, and Jack Saux; Robert Gamble, Naveed Khan, and Harry McGaw

Offered in:  Baton Rouge, Covington, Houma

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